I think I have to go back to the original list to understand the selection of works, because it seems a bit odd to me. Definitely different from most compilations of the "most important sf works" and similar. Some of them I also don't understand exactly why they ended up in the SF/F subset, but definitions of genre boundaries is something you can argue about endlessly. Nevertheless, I like these lists, and I like this one because I have actually read not so few of them: 47 out of 149, that's nearly a third!
So, the ones I have read are in bold, and the ones on my reading list (sort of) are marked with an *asterisk.
- Douglas Adams: The Hitchhiker's Guide to the Galaxy (1979)
- Brian W Aldiss: Non-Stop (1958)
- Isaac Asimov: Foundation (1951)
- Margaret Atwood: The Blind Assassin (2000)
- *Margaret Atwood: The Handmaid's Tale (1985)
- Paul Auster: In the Country of Last Things (1987)
- J.G. Ballard: The Drowned World (1962)
- J.G. Ballard: Crash (1973)
- J.G. Ballard: Millennium People (2003)
- *Iain Banks: The Wasp Factory (1984)
- Iain M Banks: Consider Phlebas (1987)
- Clive Barker: Weaveworld (1987)
- Nicola Barker: Darkmans (2007)
- Stephen Baxter: The Time Ships (1995)
- *Greg Bear: Darwin's Radio (1999)
- William Beckford: Vathek (1786)
- Alfred Bester: The Stars My Destination (1956)
- Ray Bradbury: Fahrenheit 451 (1953)
- Poppy Z Brite: Lost Souls (1992)
- Charles Brockden Brown: Wieland (1798)
- Algis Budrys: Rogue Moon (1960)
- Mikhail Bulgakov: The Master and Margarita (1966)
- Edward Bulwer-Lytton: The Coming Race (1871)
- Anthony Burgess: A Clockwork Orange (1960)
- Anthony Burgess: The End of the World News (1982)
- Edgar Rice Burroughs: A Princess of Mars (1912)
- William Burroughs: Naked Lunch (1959)
- Octavia Butler: Kindred (1979)
- Samuel Butler: Erewhon (1872)
- Italo Calvino: The Baron in the Trees (1957)
- Ramsey Campbell: The Influence (1988)
- Lewis Carroll: Alice's Adventures in Wonderland (1865)
- Lewis Carroll: Through the Looking-Glass, and What Alice Found There (1871)
- Angela Carter: Nights at the Circus (1984)
- Angela Carter: The Passion of New Eve (1977)
- Michael Chabon: The Amazing Adventures of Kavalier and Clay (2000)
- Arthur C Clarke: Childhood's End (1953)
- GK Chesterton: The Man Who Was Thursday (1908)
- *Susanna Clarke: Jonathan Strange and Mr Norrell (2004)
- Michael G Coney: Hello Summer, Goodbye (1975)
- Douglas Coupland: Girlfriend in a Coma (1998)
- Mark Danielewski: House of Leaves (2000)
- Marie Darrieussecq: Pig Tales (1996)
- Samuel R Delaney: The Einstein Intersection (1967)
- Philip K Dick: Do Androids Dream of Electric Sheep? (1968)
- Philip K Dick: The Man in the High Castle (1962)
- Thomas M Disch: Camp Concentration (1968)
- Umberto Eco: Foucault's Pendulum (1988)
- Michel Faber: Under the Skin (2000)
- John Fowles: The Magus (1966)
- Neil Gaiman: American Gods (2001)
- Alan Garner: Red Shift (1973)
- William Gibson: Neuromancer (1984)
- Charlotte Perkins Gilman: Herland (1915)
- William Golding: Lord of the Flies (1954)
- Joe Haldeman: The Forever War (1974)
- M John Harrison: Light (2002)
- Nathaniel Hawthorne: The House of the Seven Gables (1851)
- Robert A Heinlein: Stranger in a Strange Land (1961)
- Frank Herbert: Dune (1965)
- Hermann Hesse: The Glass Bead Game (1943)
- Russell Hoban: Riddley Walker (1980)
- James Hogg: The Private Memoirs and Confessions of a Justified Sinner (1824)
- Michel Houellebecq: Atomised (1998)
- Aldous Huxley: Brave New World (1932)
- Kazuo Ishiguro: The Unconsoled (1995)
- Shirley Jackson: The Haunting of Hill House (1959)
- Henry James: The Turn of the Screw (1898)
- PD James: The Children of Men (1992)
- Richard Jefferies: After London; Or, Wild England (1885)
- Gwyneth Jones: Bold as Love (2001)
- Franz Kafka: The Trial (1925)
- Daniel Keyes: Flowers for Algernon (1966)
- Stephen King: The Shining (1977)
- Marghanita Laski: The Victorian Chaise-longue (1953)
- CS Lewis: The Chronicles of Narnia (1950-56) (Book 1 at least)
- Joseph Sheridan Le Fanu: Uncle Silas (1864)
- Stanislaw Lem: Solaris (1961)
- Ursula K Le Guin: The Earthsea series (1968-1990)
- Ursula K Le Guin: The Left Hand of Darkness (1969)
- Doris Lessing: Memoirs of a Survivor (1974)
- MG Lewis: The Monk (1796)
- David Lindsay: A Voyage to Arcturus (1920)
- Ken MacLeod: The Night Sessions (2008)
- Hilary Mantel: Beyond Black (2005)
- Michael Marshall Smith: Only Forward (1994)
- Richard Matheson: I Am Legend (1954)
- Charles Maturin: Melmoth the Wanderer (1820)
- Patrick McCabe: The Butcher Boy (1992)
- Cormac McCarthy: The Road (2006)
- Jed Mercurio: Ascent (2007)
- *China Miéville: The Scar (2002)
- Andrew Miller: Ingenious Pain (1997)
- Walter M Miller Jr: A Canticle for Leibowitz (1960)
- David Mitchell: Cloud Atlas (2004)
- Michael Moorcock: Mother London (1988)
- William Morris: News From Nowhere (1890)
- Toni Morrison: Beloved (1987)
- Haruki Murakami: The Wind-up Bird Chronicle (1995)
- Vladimir Nabokov: Ada or Ardor (1969)
- Audrey Niffenegger: The Time Traveler's Wife (2003)
- Larry Niven: Ringworld (1970)
- Jeff Noon: Vurt (1993)
- Flann O'Brien: The Third Policeman (1967)
- Ben Okri: The Famished Road (1991)
- George Orwell: Nineteen Eighty-four (1949)
- Chuck Palahniuk: Fight Club (1996)
- Thomas Love Peacock: Nightmare Abbey (1818)
- Mervyn Peake: Titus Groan (1946)
- Frederik Pohl & CM Kornbluth: The Space Merchants (1953)
- John Cowper Powys: A Glastonbury Romance (1932)
- Terry Pratchett: The Discworld series (1983- ) (I have only read the first)
- *Christopher Priest: The Prestige (1995)
- Philip Pullman: His Dark Materials (1995-2000)
- François Rabelais: Gargantua and Pantagruel (1532-34)
- Ann Radcliffe: The Mysteries of Udolpho (1794)
- Alastair Reynolds: Revelation Space (2000)
- Kim Stanley Robinson: The Years of Rice and Salt (2002)
- JK Rowling: Harry Potter and the Philosopher's Stone (1997)
- *Geoff Ryman: Air (2005)
- Salman Rushdie: The Satanic Verses (1988)
- Joanna Russ: The Female Man (1975)
- Antoine de Sainte-Exupéry: The Little Prince (1943)
- José Saramago: Blindness (1995)
- Will Self: How the Dead Live (2000)
- Mary Shelley: Frankenstein (1818)
- Dan Simmons: Hyperion (1989)
- Olaf Stapledon: Star Maker (1937)
- Neal Stephenson: Snow Crash (1992)
- Robert Louis Stevenson: The Strange Case of Doctor Jekyll and Mr Hyde (1886)
- Bram Stoker: Dracula (1897)
- Rupert Thomson: The Insult (1996)
- JRR Tolkien: The Hobbit (1937)
- JRR Tolkien: The Lord of the Rings (1954-55)
- Mark Twain: A Connecticut Yankee at King Arthur's Court (1889)
- Kurt Vonnegut: Sirens of Titan (1959)
- Horace Walpole: The Castle of Otranto (1764)
- Robert Walser: Institute Benjamenta (1909)
- Sylvia Townsend Warner: Lolly Willowes (1926)
- Sarah Waters: Affinity (1999)
- HG Wells: The Time Machine (1895)
- HG Wells: The War of the Worlds (1898)
- TH White: The Sword in the Stone (1938)
- Angus Wilson: The Old Men at the Zoo (1961)
- Gene Wolfe: The Book of the New Sun (1980-83)
- Virginia Woolf: Orlando (1928)
- John Wyndham: Day of the Triffids (1951)
- John Wyndham: The Midwich Cuckoos (1957)
- Yevgeny Zamyatin: We (1924)